What is Pregnenolone? Pregnenolone is a steroid hormone made primarily by the adrenal glands directly from cholesterol. It is the biochemical starting material in the production of many other steroid hormones, including progestogens, androgens, estrogens, glucocorticoids, and mineralocorticoids. Pregnenolone is also a neurosteroid produced in the brain, which affects synaptic functioning, protects nerves and brain … Continue reading Pregnenolone